WNK1 (1-494)

ID psp02050
Organism Rattus norvegicus
Length 494

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
36318922 - Negative

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp04120 WNK1 1-2126 - ✓
psp02050 WNK1 (1-494) 1-494 -
psp02170 WNK1 (480-1242) 480-1242 -
psp04834 WNK1 (209-479) 209-479 -

Orthologs and Paralogs

ID Name Organism Length
psp03891 WNK4 Homo sapiens 1243
psp01575 WNK1 Homo sapiens 2382
psp00692 WNK Drosophila melanogaster 2253
psp00106 WNK (1001-2253) Drosophila melanogaster 1253
psp01481 WNK (1-845) Drosophila melanogaster 845
psp01866 WNK (846-1000) Drosophila melanogaster 155
psp02018 WNK (1-1000) Drosophila melanogaster 1000
psp02968 WNK1 1-494-TDP-43 Synthetic 635
psp03053 WNK1 1-494-FUS Synthetic 761
psp02085 WNK1 1-494 Homo sapiens 494
psp03125 KS-WNK1 Rattus norvegicus 1719
psp02435 KS-WNK1 C2→S Rattus norvegicus 1719
psp02587 KS-WNK1 C4→S Rattus norvegicus 1719
psp04115 KS-WNK1 C6→S Rattus norvegicus 1719
psp00083 KS-WNK1 Δ30 Rattus norvegicus 1689

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence