b-catenin

Synonyms: PRO2286, CTNNB, Beta-catenin, Catenin beta-1, CTNNB1, OK/SW-cl.35

ID psp01490
Organism Homo sapiens
Length 781
Source UniProt: P35222

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
37977121 Positive Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01490 b-catenin 1-781 - ✓
psp02037 β-catenin ΔNC 131-669 -
psp04641 β-catenin ΔN 152-781 -
psp01305 β-catenin S33Y - S33Y
psp01585 β-catenin S33Y (aroC) - S33Y, Y670A, F683A, W690A, Y709A, Y716A, F719A, Y724A, Y748A, W776A, F777A
psp03332 β-catenin S33Y (aroNC) - W25A, Y30A, S33Y, Y64A, W66A, F70A, F74A, Y86A, F99A, F114A, Y670A, F683A, W690A, Y709A, Y716A, F719A, Y724A, Y748A, W776A, F777A
psp04750 β-catenin S33Y (aroN) - W25A, Y30A, S33Y, Y64A, W66A, F70A, F74A, Y86A, F99A, F114A
psp00024 β-catenin (aroSept4 IDR) - -
psp02040 β-catenin (N-terminal Sept4 IDR) - -
psp04703 β-catenin (N-terminal SNX18 IDR) - -

Orthologs and Paralogs

No orthologs or paralogs found for this protein in the database.

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence