NUP98 LCD (1-497)

ID psp01438
Organism Homo sapiens
Length 497

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
33469149 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01356 NUP98 1-1817 - ✓
psp01438 NUP98 LCD (1-497) 1-497 -
psp00706 NUP98 IDR (38× FG repeats) 1-469 -
psp00774 Nup98 1-505 1-505 -
psp01569 NUP98N(1-515) 1-515 -
psp04645 NUP98 IDR (36× FG repeats) 1-446, 1816-1817 -
psp00060 NUP98-PRRX1 - -
psp01256 NUP98-KDM5A - -
psp01350 NUP98-HOXA9 - -
psp04300 NUP98-NSD1 - -

Orthologs and Paralogs

ID Name Organism Length
psp02557 NUP54 Arabidopsis thaliana 377
psp00467 NUP62 Arabidopsis thaliana 739
psp00136 Nup98 Oryza sativa 958
psp04068 NUP214 Homo sapiens 2090
psp01643 NUP58 Arabidopsis thaliana 513
psp01236 NUP62 (F to Y mutations) Arabidopsis thaliana 739
psp04664 NUP62 (F to S mutations) Arabidopsis thaliana 739
psp00786 NUP153 (1304-1449) Homo sapiens 146
psp04520 Nup98 FG1 Oryza sativa 336
psp04957 Nup100 1-580 Saccharomyces cerevisiae 580
psp04111 Nup116 1-725 Saccharomyces cerevisiae 725
psp04079 Nup49 1-219 Saccharomyces cerevisiae 219
psp02032 Nup98FG Drosophila melanogaster 481

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence