DVL2 ΔDEP (421-502)

ID psp00871
Organism Homo sapiens
Length 654

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
36398662 - Negative

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp03059 DVL2 1-736 - ✓
psp00871 DVL2 ΔDEP (421-502) 1-420, 503-736 -
psp01433 DVL2 ΔPDZ (263-352) 1-262, 353-736 -
psp03312 DVL2 ΔCT (515-736) 1-514 -
psp04858 DVL2 ΔIDR1 (94-252) 1-93, 253-736 -
psp04875 DVL2 ΔDIX (1-93) 94-736 -
psp03143 DVL2 D1TDP43 - -

Orthologs and Paralogs

ID Name Organism Length
psp02415 DVL2 Mus musculus 736
psp02913 GST-Dvl2 Synthetic 954
psp00067 Dvl2 ∆507-736 Mus musculus 506
psp00118 DVL2 DIX (1-114) Mus musculus 114
psp00133 DVL2 ΔDEP Mus musculus 633
psp00452 DVL2 1-418+CFR Mus musculus 476
psp00540 DVL2 ΔDEP ΔCD2 Mus musculus 595
psp01865 DVL2 ΔDEP ΔLCR3 Mus musculus 592
psp01958 Dvl2 ∆355-414 Mus musculus 676
psp01988 Dvl2 D1 Mus musculus 617
psp02543 DVL2 ΔDEP ΔLCR2 Mus musculus 598
psp02853 Dvl2 ∆DIX Mus musculus 653
psp02943 DVL2 ΔCFR Mus musculus 678
psp03045 Dvl2 ∆93-267 Mus musculus 561
psp03168 DVL2 ΔDEP ΔLCR1 Mus musculus 615
psp03345 DVL2 ΔDEP ΔLCR4 Mus musculus 619
psp03932 DVL2 ΔDEP ΔCD1 Mus musculus 620
psp03954 DVL2 1-418 Mus musculus 418
psp04124 DVL2 1-418+CD2 Mus musculus 456
psp04920 DVL2 1-418+LCR4 Mus musculus 432
psp05111 DVL2 ΔDEP ΔCFR Mus musculus 575
psp05178 Dvl2 dRE Mus musculus 716
psp02779 DVL2 ΔDEP FF-AA Mus musculus 633
psp04222 DVL2 ΔDEP VV-AA Mus musculus 633

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence