MED1
Synonyms: CRSP1, Peroxisome proliferator-activated receptor-binding protein, DRIP230, RB18A, DRIP205, Vitamin D receptor-interacting protein complex component DRIP205, Thyroid hormone receptor-associated protein complex 220 kDa component, PPAR-binding protein, PPARGBP, CRSP200, Mediator complex subunit 1, Thyroid receptor-interacting protein 2, ARC205, MED1, Mediator of RNA polymerase II transcription subunit 1, TRIP-2, Trap220, TRAP220, PBP, TRIP2, PPARBP, Activator-recruited cofactor 205 kDa component, p53 regulatory protein RB18A, TR-interacting protein 2
PS Record in Articles
| Reference (Pubmed ID) | In vitro results | In vivo results |
|---|---|---|
| 29930091 | - | Positive |
| 30449618 | Positive | Positive |
| 35355287 | - | Positive |
Protein Sequence
Sequence Variants
| ID | Name | Remain region | Mutation sites | Ref seq |
|---|---|---|---|---|
| psp00862 | MED1 | 1-1581 | - | ✓ |
| psp00578 | MED1 IDR | 948-1581 | - | |
| psp01413 | MED1 IDRXL | 601-1574 | - | |
| psp01583 | MED1 IDR | 948-1573 | - | |
| psp02320 | MED1 IDR (963-1320) | 963-1320 | - | |
| psp03832 | MED1 IDR (948-1574) | 948-1574 | - |
Orthologs and Paralogs
| ID | Name | Organism | Length |
|---|---|---|---|
| psp02174 | Med19 | Mus musculus | 244 |
| psp00852 | MED15 | Saccharomyces cerevisiae | 1081 |
| psp05059 | MED8 | Arabidopsis thaliana | 524 |
| psp01678 | AtMed19a (1-112)+HsMED19 (176-261) | Synthetic | 141 |
| psp04879 | AtMed19a (1-112)+ScMED19 (127-220) | Synthetic | 206 |
| psp01644 | MED19a (113-221) | Arabidopsis thaliana | 109 |
| psp00928 | MED8 (60Q to A) | Arabidopsis thaliana | 524 |
| psp03150 | MED8 (79Q to A) | Arabidopsis thaliana | 524 |
| psp04880 | MED8 (40Q to A) | Arabidopsis thaliana | 524 |
| psp03133 | MED13 exon 20 | Homo sapiens | 153 |
Biophysical Features
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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.
Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.
PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.
LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.
NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.
Polarity was computated by ProtScale, please refer to: ProtScale.
SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.
Protein Structure
Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.
For pLDDT, please refer to: pLDDT: Understanding local confidence