Ki-67 R12 (CBm-4)

ID psp00608
Organism Homo sapiens
Length 112

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
35513709 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01025 Ki-67 1-3256 -
psp00608 Ki-67 R12 (CBm-4) 2336-2447 G2415E, N2416E, G2419E, Q2423E, Q2425E, A2431E, A2433E, G2439E, Q2445E
psp02443 Ki-67 R8-16 1844-2928 -
psp02513 Ki-67 Δ494-2928 1-493, 2929-3256 -
psp02571 Ki-67 R16 2819-2928 -
psp03418 Ki-67 R7 1731-1842 -
psp03819 Ki-67 R14-16 2582-2689, 2700-2804, 2818-2928 -
psp04838 Ki-67 R12 2336-2447 -
psp00247 Ki-67 R12 (CBm-2) 2336-2447 K2357Q, R2359Q, K2361Q, R2362Q, R2365Q, K2366Q
psp00905 Ki-67 R12 (CBm-1) 1123-1132, 1497-1504, 2249-2251, 2357-2447 Q2358E, A2367E
psp02705 Ki-67 R12 (CBm-3) 2336-2447 A2383E, G2384E, A2386E, A2393E, S2395E, N2399E, N2401E, Q2409E
psp03961 Ki-67 R12 (Pm9) 2336-2445, 3060-3061 T2352E, T2380E, S2382E, T2389E, T2402E, T2406E, S2420E, T2426E
psp04494 Ki-67 R7 (Pm) 1731-1840, 3060-3061 S1740E, T1747E, T1775E, T1784E, T1801E, S1815E
psp04391 Ki-67 (R12)2 - -
psp04433 Ki-67 (R12)4 - -

Orthologs and Paralogs

No orthologs or paralogs found for this protein in the database.

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence