Syt1 CD K/A

ID psp00607
Organism Rattus norvegicus
Length 280

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
38980206 Negative -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp00955 Syt1 1-421 - ✓
psp00607 Syt1 CD K/A 83-140, 200-421 K85A, K86A, K87A, K89A, K90A, K91A, K93A, K95A, K98A, K104A, K107A, K111A, K114A, K119A, K133A, K137A, K200A
psp00242 Syt1 IDR (aa83-141) 83-140, 421-421 -
psp01690 Syt1 CDΔIDR (aa142-421) 142-421 -
psp03153 Syt1 CD (83-421) 83-421 -
psp04309 Syt1 ΔIDR 1-82, 142-421 -
psp02326 Syt1 C2A* C2B* - D178A, D230A, D232A, D309A, D363A, D365A
psp02955 Syt1 C2B* - D309A, D363A, D365A
psp04914 Syt1 C2A* - D178A, D230A, D232A
psp02054 Syt1 IDR K/A 83-141 K85A, K86A, K87A, K89A, K90A, K91A, K93A, K95A, K98A, K104A, K107A, K111A, K114A, K119A, K133A, K137A, K141A

Orthologs and Paralogs

ID Name Organism Length
psp00968 Syt1 80-421 Mus musculus 342
psp01576 Syt1 80-142 Mus musculus 63
psp04399 Syt1 143-421 Mus musculus 279

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence