SQSTM1-2RF (R183F/R217F)

ID psp00478
Organism Homo sapiens
Length 440

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
38994016 - Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01912 SQSTM1 1-440 - ✓
psp00478 SQSTM1-2RF (R183F/R217F) - R183F, R217F
psp00799 SQSTM1-N (1-256) 1-256 -
psp01206 SQSTM1 ΔUBA (Δ389-434) 1-388, 434-440 -
psp02486 SQSTM1 ΔPB1 (Δ10-120) 1-9, 121-440 -
psp02493 SQSTM1 PB1 2-102 -
psp02828 SQSTM1 (del PB1) 1-2, 103-440 -
psp03383 SQSTM1 (PB1-ZZ) 1-2, 174-440 -
psp04302 SQSTM1 ΔNES 1-300, 319-440 -
psp05067 SQSTM1-ΔLIR (Δ321-348) 1-320, 349-440 -
psp00425 SQSTM1 (D69A) - D69A
psp01371 SQSTM1 M404V - M404V
psp02883 SQSTM1 G425R - G425R
psp03648 SQSTM1-2RK (R183K/R217K) - R183K, R217K
psp03684 SQSTM1 P392L - P392L
psp03809 SQSTM1 L341V - L341V
psp04676 SQSTM1 (K7A) - K7A

Orthologs and Paralogs

ID Name Organism Length
psp04588 SQSTM1 Mus musculus 442

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence