PGL-3 D1-IDR-RGG

ID psp00444
Organism Caenorhabditis elegans
Length 457

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
40666952 Negative -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp00627 PGL-3 1-693 - ✓
psp00444 PGL-3 D1-IDR-RGG 1-212, 449-693 -
psp00549 PGL-3(165-693) 165-693 -
psp01418 PGL-3(434-693) 434-693 -
psp01540 PGL-3(215-693) 215-693 -
psp01718 PGL-3 (448-622) 448-622 -
psp02661 PGL-3 (1-622) 1-622 -
psp02794 PGL-3 (1-212) 1-212 -
psp02930 PGL-3 (1-447, 623-693) 1-447, 623-693 -
psp03578 PGL-3 (623-693) 623-693 -
psp03775 PGL-3(1-620) 1-620 -
psp03804 PGL-3 D2-IDR-RGG 205-693 -
psp03908 PGL-3(1-215) 1-215 -
psp04633 PGL-3 (1-447) 1-447 -
psp04736 PGL-3 (205-447) 205-447 -
psp04839 PGL-3 (448-693) 448-693 -
psp02544 PGL-3 RGG_mut - R634L, G635R, G636R, R638L, G639R, G640R, R650L, G651R, G652R, R661L, G662R, G663R, R665L, G666R, G667R, R690L, G691R, G692R
psp04769 PGL-3 (1-447, 3x(GGGGS), 623-693) - -

Orthologs and Paralogs

No orthologs or paralogs found for this protein in the database.

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence