IGF2BP2

Synonyms: IMP2, Insulin-like growth factor 2 mRNA-binding protein 2, IGF2 mRNA-binding protein 2, VICKZ family member 2, VICKZ2, IGF-II mRNA-binding protein 2, Hepatocellular carcinoma autoantigen p62, IMP-2, IGF2BP2

ID psp05020
Organism Homo sapiens
Length 599
Source UniProt: Q9Y6M1

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
38657551 - Positive

Protein Sequence

Sequence Variants

No protein variants available for this protein.

Orthologs and Paralogs

ID Name Organism Length
psp00811 IGF2BP1 Homo sapiens 577
psp00226 IGF2BP1 (KH1-4) Homo sapiens 386
psp01455 IGF2BP1 (KH3-4) Homo sapiens 176
psp01671 IGF2BP1 IDR Homo sapiens 247
psp03439 IGF2BP1 (aa157-KH2) Homo sapiens 205
psp04345 IGF2BP1 (RRM1-2) Homo sapiens 156
psp04388 IGF2BP1 (RRM1-KH3) Homo sapiens 472
psp04616 IGF2BP1 (KH1-2) Homo sapiens 170
psp04740 IMP1C Homo sapiens 388
psp04913 IGF2BP1 IDR DEL Homo sapiens 267
psp05000 IGF2BP1 (RRM1-KH2) Homo sapiens 361
psp00334 IGF2BP1 IDR MUT Homo sapiens 247

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence