cGAS

Synonyms: Cyclic GMP-AMP synthase, XELAEV_18029463mg

ID psp04488
Organism Xenopus laevis
Length 745
Source UniProt: A0A974CRI2

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
33606975 Positive -

Protein Sequence

Sequence Variants

No protein variants available for this protein.

Orthologs and Paralogs

ID Name Organism Length
psp01082 cGAS Homo sapiens 522
psp04043 cGAS Macaca mulatta 573
psp01463 cGAS Sus scrofa 495
psp04291 cGAS Mus musculus 507
psp00123 cGAS Danio rerio 592
psp05133 cGAS Leontocebus fuscicollis 523
psp00991 cGAS Gorilla gorilla 447
psp00188 cGAS Chi4.2 Synthetic 366
psp01692 cGAS Chi3.1 Synthetic 366
psp01998 cGAS Chi4.1 Synthetic 363
psp02985 cGAS Chi1 Synthetic 364
psp04811 cGAS Chi3.3 Synthetic 364
psp04859 cGAS Chi2 Synthetic 363
psp01339 cGAS Chi3.2 Synthetic 363
psp01879 cGAS Chi3.2 K187N/L195R Synthetic 363
psp02844 cGAS E402A Homo sapiens 522
psp02614 cGAS-Cterm Homo sapiens 366
psp02784 cGAS-Nterm Homo sapiens 157
psp01020 cGAS-Cterm Mus musculus 361

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence