LINE-1 ORF2p

Synonyms: ORF2p [Includes: Reverse transcriptase, EC 2.7.7.49; Endonuclease, EC 3.1.21.-], LINE-1 retrotransposable element ORF2 protein

ID psp00694
Organism Homo sapiens
Length 1275
Source UniProt: O00370

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
37114770 - Positive

Protein Sequence

Sequence Variants

No protein variants available for this protein.

Orthologs and Paralogs

ID Name Organism Length
psp03938 ORF1 Homo sapiens 338
psp00345 Line-1 ORF1 K3E/K4E/R7E/K8E Homo sapiens 338
psp00362 Line-1 ORF1 K3A Homo sapiens 338
psp00364 Line-1 ORF1 L93P Homo sapiens 338
psp00437 ORF1p StammerAAA Homo sapiens 338
psp01171 LINE-1 ORF1 S27D Homo sapiens 338
psp02630 Line-1 ORF1 K3A/K4A/R7A/K8A Homo sapiens 338
psp02866 LINE-1 ORF1p R261A Homo sapiens 338
psp03625 LINE-1 ORF1p (K3A/K4A) Homo sapiens 338
psp04110 ORF1p StammerAEA Homo sapiens 338
psp04186 Line-1 ORF1 K3E/K4E Homo sapiens 338
psp04846 Line-1 ORF1 K4A Homo sapiens 338
psp04857 Line-1 ORF1 R7E/K8E Homo sapiens 338
psp00376 Line-1 ORF1 53-338 Homo sapiens 286
psp00817 ORF1 157-338 Homo sapiens 182
psp00950 Line-1 ORF1 1-53 Homo sapiens 53
psp01560 Line-1 ORF1 1-141 Homo sapiens 141
psp02241 Line-1 ORF1 66-338 Homo sapiens 273
psp02242 Line-1 ORF1 1-152 Homo sapiens 152
psp03318 ORF1p StammerDel (Δ91-93) Homo sapiens 335
psp03698 Line-1 ORF1 1-131 Homo sapiens 131
psp03709 Line-1 ORF1 53-152 Homo sapiens 100

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence